{"id":16716,"date":"2026-09-21T09:55:34","date_gmt":"2026-09-21T09:55:34","guid":{"rendered":"https:\/\/agrauxine.com\/?p=16716"},"modified":"2026-09-21T09:59:04","modified_gmt":"2026-09-21T09:59:04","slug":"liquid-or-solid-fermentation-does-the-choice-really-matter","status":"publish","type":"post","link":"https:\/\/agrauxine.com\/en\/liquid-or-solid-fermentation-does-the-choice-really-matter\/","title":{"rendered":"Liquid or solid fermentation: does the choice really matter?"},"content":{"rendered":"\n<p>When developing and industrializing microbial solutions, fermentation is not simply about choosing a production technology. The right approach depends on the microorganism, the target product, the scale and, increasingly, the sustainability requirements of the process.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The advantages of solid-state fermentation<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"--col-larg:33.33%\">\n<figure class=\"wp-block-image size-large is-style-bulle\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"789\" src=\"https:\/\/agrauxine.com\/wp-content\/uploads\/Capture-decran-2025-07-31-100749-2-1024x789.jpg\" alt=\"\" class=\"wp-image-13861\" srcset=\"https:\/\/agrauxine.com\/wp-content\/uploads\/Capture-decran-2025-07-31-100749-2-1024x789.jpg 1024w, https:\/\/agrauxine.com\/wp-content\/uploads\/Capture-decran-2025-07-31-100749-2-300x231.jpg 300w, https:\/\/agrauxine.com\/wp-content\/uploads\/Capture-decran-2025-07-31-100749-2-768x592.jpg 768w, https:\/\/agrauxine.com\/wp-content\/uploads\/Capture-decran-2025-07-31-100749-2.jpg 1285w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"--col-larg:66.66%\">\n<p><strong>Liquid fermentation<\/strong>&nbsp;remains a powerful and versatile platform, particularly for organisms and products that require highly controlled submerged conditions. <strong>Solid-state fermentation (SSF)<\/strong>, however, offers a different set of opportunities, particularly for filamentous fungi. By growing microorganisms on a moist solid substrate rather than in a liquid medium, SSF reduces <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>water use, <\/li>\n\n\n\n<li>wastewater, <\/li>\n\n\n\n<li>and energy <\/li>\n<\/ul>\n\n\n\n<p>vs. liquid fermentation (due to less media prep, seed trains, and CIP), though scale-up challenges, like heat\/mass transfer, exist.  <br>Benefits, though, depend on the organism, substrate, and process design.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Solid-state fermentation, an Agrauxine expertise<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"--col-larg:66.66%\">\n<p>But the technology itself is only part of the equation. Successful industrialization requires <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>the right strain, <\/strong><\/li>\n\n\n\n<li><strong>process understanding, <\/strong><\/li>\n\n\n\n<li><strong>scale-up expertise <\/strong><\/li>\n\n\n\n<li><strong>and manufacturing infrastructure. <\/strong><\/li>\n<\/ul>\n\n\n\n<p>This is where Agrauxine by Lesaffre brings a differentiated capability, with more than <strong>20 years of experience in solid-state fermentation and industrial production of filamentous microorganisms.<\/strong> Our Loches, France, site supports projects from feasibility and process development through scale-up and toll manufacturing.<br>Our capabilities extend to Van Wert, Ohio, where Agrauxine operates a site specializing in formulation and North American market access for filamentous fungi-based products.<\/p>\n\n\n\n<p>From <strong>agricultural biocontrol and biostimulation to other emerging applications<\/strong>, we are continuing to explore how SSF can help our partners develop and manufacture microbial solutions at industrial scale.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"--col-larg:33.33%\">\n<figure class=\"wp-block-image size-large is-style-bulle\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"864\" src=\"https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-1024x864.jpg\" alt=\"\" class=\"wp-image-13813\" srcset=\"https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-1024x864.jpg 1024w, https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-300x253.jpg 300w, https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-768x648.jpg 768w, https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-1536x1297.jpg 1536w, https:\/\/agrauxine.com\/wp-content\/uploads\/substrat-solide-agrauxine-1-2048x1729.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/agrauxine.com\/en\/custom-fermentation\/\">Learn more about our custom fermentation<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>If you are working on a filamentous microorganism project and looking at <strong>feasibility, scale-up, CDMO or toll manufacturing<\/strong>, it would be great to connect and exchange on how SSF could fit your needs.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>When developing and industrializing microbial solutions, fermentation is not simply about choosing a production technology. The right approach depends on the microorganism, the target product, the scale and, increasingly, the sustainability requirements of the process.<\/p>\n","protected":false},"author":13,"featured_media":13861,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[123],"tags":[],"class_list":["post-16716","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","cat-123-id"],"acf":{"header":13813},"_links":{"self":[{"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/posts\/16716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/comments?post=16716"}],"version-history":[{"count":2,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/posts\/16716\/revisions"}],"predecessor-version":[{"id":16775,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/posts\/16716\/revisions\/16775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/media\/13861"}],"wp:attachment":[{"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/media?parent=16716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/categories?post=16716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agrauxine.com\/en\/wp-json\/wp\/v2\/tags?post=16716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}